Relação entre benefício e risco em interações medicamentosas nas prescrições médicas de um hospital universitário no estado de São Paulo / Benefit-risk relationship in drug interactions in prescriptions from a university hospital in the state of São Paulo / Relación beneficio-riesgo en interacciones medicamentosas en prescripciones de un hospital universitario del estado de São Paulo

Objetivo: Avaliar interações medicamentosas (IM), em que os riscos se so- brepõem aos benefícios (nível I) ou os benefícios se sobrepõem aos riscos (nível II); a partir da análise retrospectiva de prescrições médicas em um Hospital Universitário no estado de São Paulo, Brasil. Métodos: Foram analisadas 19762 prescrições médicas des- tinadas à farmácia do hospital, de janeiro a setembro de 2009; com o auxílio de programas sobre IM, para categorizar IM de nível I e II. Resultados: Na análise 26,53% apresentaram IM, em que 23,64% foram classificadas em nível I e 76,35% em nível II. Dentre as IM com maior frequência no nível I, estavam: ácido acetilsalicílico (AAS) e clopidogrel, AAS e heparina, captopril e espironolactona, digoxina e hidroclorotiazida. Houve uma redução em percentual de IM de nível I, comparando janeiro representado por 26,5% e setembro representado por 18,4%. Já nas IM de nível II, tem-se as seguintes associações com maior frequência: AAS e propranolol, AAS e insulina regular humana, AAS e ate- nolol, AAS e enalapril, AAS e carvedilol. Conclusão: A atuação dos farmacêuticos cola- borou à redução de IM de nível I, devido à intervenção por meio de comunicação estabe- lecida com os prescritores; sinalizando a importância da equipe interprofissional em saúde.

Objective: To evaluate drug interactions (MI), in which risks outweigh the benefits (level I) or benefits outweigh the risks (level II); from the retrospective analysis of medical prescriptions in a University Hospital in the state of São Paulo, Brazil. Methods: 19,762 prescriptions destined to the hospital pharmacy were analyzed, from January to September 2009; with the help of programs on MI, to categorize level I and II MI. Results: In the analysis 26.53% presented MI, in which 23.64% were classified in level I and 76.35% in level II. Among the most frequent level I MI were: acetylsalicylic acid (ASA) and clopidogrel, ASA and heparin, captopril and spironolactone, digoxin and hydrochlorothiazide. There was a reduction in the percentage of level I MI, comparing January, which accounted for 26.5%, and September, which accounted for 18.4%. As for level II MI, the following associations were more frequent: ASA and propranolol, ASA and regular human insulin, ASA and atenolol, ASA and enalapril, ASA and carvedilol. Conclusion: The role of pharmacists collaborated to the reduction of level I MI, due to the intervention by means of communication established with the prescribers; signaling the importance of the interprofessional health team.

Objetivo: Evaluar las interacciones medicamentosas (IM), en las que los riesgos superan a los beneficios (nivel I) o los beneficios superan a los riesgos (nivel II); a partir del análisis retrospectivo de las prescripciones médicas en un Hospital Universitario del estado de São Paulo, Brasil. Métodos: Se analizaron 19.762 prescripciones destinadas a la farmacia del hospital, de enero a septiembre de 2009; con la ayuda de programas sobre IM, para categorizar los IM de nivel I y II. Resultados: En el análisis el 26,53% presentaron IM, en el que el 23,64% se clasificaron en nivel I y el 76,35% en nivel II. Entre los IM de nivel I más frecuentes estaban: ácido acetilsalicílico (AAS) y clopidogrel, AAS y heparina, captopril y espironolactona, digoxina e hidroclorotiazida. Hubo una reducción del porcentaje de IM de nivel I, comparando enero, que supuso el 26,5%, y septiembre, que supuso el 18,4%. En cuanto a los IM de nivel II, fueron más frecuentes las siguientes asociaciones: AAS y propranolol, AAS e insulina humana regular, AAS y atenolol, AAS y enalapril, AAS y carvedilol. Conclusiones: El papel de los farmacéuticos colaboró a la reducción de las IM de nivel I, debido a la intervención mediante la comunicación establecida con los prescriptores; señalando la importancia del equipo sanitario interprofesional.

A segurança do paciente e a avaliação do risco de quedas / Patient safety and fall-risk assessment / Seguridad del paciente y evaluación de riesgo de caída

Objetivo: Avaliar os pacientes hospitalizados quanto ao risco de quedas. Métodos: Estudo transversal, realizado por meio da aplicação da escala de Morse e registros de prontuários. Realizou-se estatísticas descritivas e Teste Qui-quadrado de Pearson, adotando-se o nível de 5%. Resultados: Dos 244 participantes, 139 (57%) eram do sexo masculino, 86 (47,5%) idosos, 116 (47,5%) com companheiro, 112 (45,9%) pardos e 173 (70,9%) com baixa escolaridade. O risco de quedas foi associado ao histórico de quedas (p=0,000), diagnóstico secundário (p<0,001), deambulação (p=0,002), marcha (p<0,001) e estado mental (p<0,000). A maioria dos entrevistados 194 (79,5%) estão sob um risco moderado a alto de sofrer quedas da própria altura 37 (15,2%), ocorridas no quarto ou na enfermaria 38 (15,6%). Conclusão: Observou-se um risco moderado a alto para quedas nos pacientes hospitalizados, o que aponta para a necessidade de implementação de políticas de segurança do paciente para garantir a qualidade da assistência. (AU)

Objective: Assess hospitalized patients for the risk of falls. Methods: Cross-sectional study, carried out through the application of the Morse scale and medical records. Descriptive statistics and Pearson's Chi-square test were performed, adopting the 5% level. Results: Of the 244 participants, 139 (57%) were male, 86 (47.5%) elderly, 116 (47.5%) with a partner, 112 (45.9%) brown and 173 (70.9%) with low education level. The risk of falls was associated with a history of falls (p = 0.000), secondary diagnosis (p <0.001), walking (p = 0.002), gait (p <0.001) and mental status (p <0.000). Most respondents 194 (79.5%) are at moderate to high risk of suffering falls from their own height 37 (15.2%), in their bedroom or in the ward 38 (15.6%). Conclusion: There was a moderate to high risk for falls in hospitalized patients, which points to the need of implementing patient safety policies in order to guarantee quality of care. (AU)

Objetivo: Evaluar a los pacientes hospitalizados por el riesgo de caídas. Métodos: Estudio transversal, realizado a través de la aplicación de la escala Morse y registros médicos. Se realizaron estadísticas descriptivas y la prueba de Chi-cuadrado de Pearson, adoptando el nivel del 5%. Resultados: De los 244 participantes, 139 (57%) eran hombres, 86 (47.5%) ancianos, 116 (47.5%) con una pareja, 112 (45.9%) marrones y 173 (70.9%) con baja educacion. El riesgo de caídas se asoció con antecedentes de caídas (p = 0.000), diagnóstico secundario (p <0.001), caminar (p = 0.002), marcha (p <0.001) y estado mental (p <0.000). La mayoría de los encuestados 194 (79.5%) tienen un riesgo moderado a alto de sufrir caídas desde su propia altura 37 (15.2%), ocurriendo en el dormitorio o en la sala 38 (15.6%). Conclusión: Hubo un riesgo moderado a alto de caídas en pacientes hospitalizados, lo que apunta a la necesidad de implementar políticas de seguridad del paciente para garantizar la calidad de la atención. (AU)

Predictors of short-term mortality in HIV-infected patients admitted to intensive care unit / Fatores preditores de mortalidade de curto prazo em pacientes infectados com HIV admitidos em unidade de terapia intensiva

INTRODUCTIONn: Historically, complications of HIV infection have been related to admissions to the Intensive Care Unit (ICU). Despite therapeutic advances, the results of the analysis of prognostic factors in patients with HIV/AIDS have varied, including late diagnosis and failure to adhere to antiretroviral treatment. OBJECTIVE: To evaluate the predictors of short-term mortality in HIV-infected patients admitted to the ICU, as well as their sociodemographic and clinical characteristics. METHODS: A retrospective cohort study including patients admitted to the ICU of a teaching hospital from 2003 through 2012. Data were collected from medical records after the Institutional Review Board approval. RESULTS: 148 HIV-infected patients were identified and 131 were eligible. Among included patients, 42.75% were HIV new diagnoses and 5.34% had no information about the time of diagnosis. The main reasons for admission to the ICU were respiratory failure and sepsis while mortality was 70.23% between 2003 and 2012. Among the risk factors for mortality were low albumin, high APACHE, low CD4+ T lymphocyte count, and not using antiretroviral therapy. CONCLUSION: Despite the availability of diagnosis and treatment for HIV-infected individuals, the number of new cases of advanced Aids diagnosed in high-complexity services such as ICU is high, as well as the non-use of combination antiretroviral therapy. It is necessary to strengthen anti-HIV screening to detect and treat more cases in the early stages.

INTRODUÇÃO: Historicamente, as complicações da infecção pelo HIV estavam relacionadas às internações em Unidade de Terapia Intensiva (UTI). Apesar dos avanços terapêuticos, os fatores prognósticos em pacientes com HIV/AIDS têm variado, incluindo diagnóstico tardio e não adesão ao tratamento antirretroviral. OBJETIVO: Avaliar os fatores preditores de mortalidade a curto prazo em pacientes infectados pelo HIV internados em UTI, bem como suas características sociodemográficas e clínicas. MÉTODOS: Estudo de coorte retrospectivo incluindo pacientes internados na UTI de um hospital universitário entre 2003 a 2012. Os dados foram coletados dos prontuários médicos após a aprovação pelo Comitê de Ética em Pesquisa com Seres Humanos. RESULTADOS: 148 pacientes infectados pelo HIV foram identificados e 131 eram elegíveis. Entre os pacientes incluídos, 42,75% possuíam diagnósticos recente de HIV e 5,34% não possuíam informação sobre o momento do diagnóstico. Os principais motivos de admissão na UTI foram insuficiência respiratória e sepse, enquanto a mortalidade foi 70,23% entre 2003 e 2012. Entre os fatores de risco para mortalidade identificou-se albumina baixa, APACHE alto, baixa contagem de linfócitos T CD4+ e não uso de terapia antirretroviral. CONCLUSÃO: Apesar da disponibilidade de diagnóstico e tratamento para indivíduos infectados pelo HIV, é elevado o número de casos novos em estágio avançado de Aids diagnosticados em serviços de alta complexidade, como UTI, e o não uso de terapia antirretroviral combinada. É necessário fortalecer a triagem anti-HIV, bem como aumentar a repetição da testagem anti-HIV para detectar e tratar mais casos em estágios iniciais.

Nutrition impact symptoms, sarcopenia, and malnutrition in hospitalized patients / Sintomas de impacto nutricional, sarcopenia e desnutrição em pacientes hospitalizados

INTRODUCTION: Nutrition Impact Symptoms (NIS) are common in hospitalized patients and can be aggravated in the presence of malnutrition. OBJECTIVE: To verify the presence of NIS and its association with sociodemographic and clinical variables, sarcopenia phenotype, and nutritional status of individuals hospitalized. METHODS: This is a cross-sectional study with hospitalized patients, of both sexes and ≥50 years old. Patient-Generated Subjective Global Assessment (PG-SGA), handgrip strength (HGS), gait speed GS), and anthropometric measurements were performed up to 48 hours after admission. NIS was obtained through PG-SGA and stratified into two groups: <3 and ≥3 symptoms. The chi-square test (χ2) was performed, and a 5% significance level was adopted. RESULTS: A total of 90 patients (65.4±9.67 years) were studied, with the majority of men (56.7%), older people (70.0%), married (68.9%), low economic class (72.2%), without work activity (70.5%), with two previous diseases (60.0%), overweight by body mass index (46.7%) and adequate adductor pollicis muscle thickness (83.3%). The most prevalent NIS were "dry mouth", "anorexia", and "smells sick" respectively 31.1%, 30.0%, and 16.7%. There was an association between NIS and SARC-F score (p=0.002), handgrip strength (p=0.016), the status of sarcopenia (p=0.020), PG-SGA (p<0.001), and economic status (p=0.020). CONCLUSION: The identification of NIS is common, and may infer negative nutritional status and functional performance of patients. The use of protocols to identify NIS during hospitalization should be considered to minimize the negative impact on nutritional status.

INTRODUÇÃO: Sintomas de impacto nutricional (SIN) são comuns em pacientes hospitalizados e estes podem ser agravados na presença da desnutrição. OBJETIVO: Verificar a presença de SIN e sua associação com as variáveis sociodemográficas, clínicas, fenótipo de sarcopenia e estado nutricional de indivíduos hospitalizados. MÉTODOS: Trata-se de estudo transversal com pacientes internados, de ambos os sexos e idade ≥ 50 anos. Realizou-se Avaliação Subjetiva Global produzida pelo Paciente (ASG-PPP), força de preensão palmar (FPP), velocidade de caminhada (VC) e medidas antropométricas até 48 horas da admissão. Os SIN foram obtidos por meio da ASG-PPP e compilados em <3 ou ≥3 sintomas. Realizou-se o teste de qui-quadrado (χ2). Adotou-se nível de significância de 5%. RESULTADOS: Um total de 90 pacientes (65,4±9,67 anos), sendo a maioria homem (56,7%), idoso (70,0%), casado (68,9%), classe econômica baixa (72,2%), sem atividade de trabalho (70,5%), com uma a duas doenças pregressas (60,0%), excesso de peso ao índice de massa corporal (46,7%) e adequada espessura do músculo adutor do polegar (83,3%). Os SIN "boca seca", "anorexia" e "cheiros enjoam" foram os mais prevalentes, respectivamente 31,1%, 30,0% e 16,7%. Houve associação dos SIN com as variáveis que compõem o fenótipo de sarcopenia: o escore SARC-F (p=0,002) e FPP (p=0,016), status de sarcopenia (p=0,020), ASG-PPP (p<0,001) e classe econômica (p=0,020). CONCLUSÃO: A identificação de SIN é comum, podendo inferir negativamente no estado nutricional e desempenho funcional dos pacientes. Considerar o uso de protocolos para identificação dos SIN durante a hospitalização a fim de minimizar a repercussão negativa no estado nutricional.

Complicação e retenção de cateter central de inserção periférica em recém-nascido: relatos de casos / Complicación y retención de catéter central de inserción periférica en recién nacido: informes de casos / Complication and retention of peripheral insertion central catheter in newborn: case reports

Objetivo: relatar casos de complicação e retenção de cateter central de inserção periférica em recém-nascidos. Método: Relato de caso sobre dois casos de enovelamento e retenção de cateter central de inserção periférica em uma Unidade de Terapia Intensiva Neonatal de um hospital no Sul do Brasil, entre maio e outubro de 2022. Resultados: No primeiro caso ocorreu dificuldade na remoção do cateter logo após sua inserção, com necessidade de remoção cirúrgica. No segundo identificou-se pela radiografia o enovelamento na fossa antecubital do membro superior neonatal, sem migração da ponta para região central, apesar de apresentar refluxo sanguíneo, sendo removido por tração manual. Conclusão: a formação de novelos ou nós em cateter central de inserção periférica e retenção tratam-se de complicações raras. Estar atento a este acontecimento possibilita a construção de evidências e estratégias de prevenção e manejo adequado na prática profissional.

Objetivo: reportar casos de complicación y retención de catéter central de inserción periférica en recién nacidos internados en la Unidad de Terapia Intensiva Neonatal. Método: estudio descriptivo, del tipo relato de caso, realizado entre mayo y octubre de 2022, en un hospital en el Sur de Brasil. Resultados: se han identificado dos casos de ennegrecimiento/formación de nudo y retención de catéter central de inserción periférica. En el primer caso ocurrió dificultad en la extracción del catéter inmediatamente después de su inserción, con necesidad de extracción quirúrgica. En el segundo caso, se identificó por la radiografía el ennegrecimiento en la fosa antecubital del miembro superior neonatal, sin migración de la punta hacia la región central, a pesar de presentar reflujo sanguíneo, siendo removido por tracción manual, sin resistencia e intercorgencias. Conclusión: la formación de ovillos o nudos en catéter central de inserción periférica y retención se tratan de complicaciones raras. Estar atento a este acontecimiento posibilita la construcción de evidencias y estrategias de prevención y manejo adecuado en la práctica profesional.

Objective: to report cases of complication and retention of central peripheral insertion catheter in newborns admitted to the Neonatal Intensive Care Unit. Method: descriptive case report study, conducted between May and October 2022, in a hospital in southern Brazil. Results: two cases of node folding/formation and retention of central peripheral insertion catheter were identified. In the first case, there was difficulty in removing the catheter soon after its insertion, requiring surgical removal. In the second case, the folding in the antecubital fossa of the neonatal upper limb was identified by radiography, without migration from the tip to the central region, despite presenting blood reflux, being removed by manual traction, without resistance or intercurrences. Conclusion: the formation of skeins or nodes in central catheter of peripheral insertion and retention are rare complications. Being aware of this event enables the construction of evidence and prevention strategies and proper management in professional practice.

Percepção de enfermeiras sobre a identificação do paciente como segurança na assistência a criança hospitalizada / Percepción del personal de enfermería de la identificación del paciente como medida de seguridad en la atención a los niños hospitalizados / Perception of nurses on patient identification as safety in the care of hospitalized child

Objetivo: identificar a percepção de enfermeiras que atuam em unidade pediátrica sobre medidas de segurança do paciente. Método: estudo qualitativo, descritivo e exploratório, realizado em um hospital público de Pernambuco, Brasil. Participaram seis enfermeiras atuantes na pediatria. A coleta de dados foi realizada entre novembro e fevereiro de 2021 mediante entrevistas semiestruturadas, a análise dos dados foi realizada por meio da investigação do conteúdo. Resultados: identificou-se três categorias a partir da análise dos resultados, sendo elas a percepção das enfermeiras sobre segurança do paciente, as barreiras de identificação do paciente na unidade pediátrica e a pulseiras de identificação: estratégia para mitigar erros na unidade pediátrica. Considerações finais: foi possível perceber que as enfermeiras acreditam na importância da identificação dos pacientes como uma estratégia para minimizar a ocorrência de erros relacionados a medicamentos e enfatizam que esse ato proporciona uma segurança maior aos profissionais durante a execução dos procedimentos.

Objetivo: identificar la percepción de las enfermeras que trabajan en una unidad pediátrica sobre las medidas de seguridad del paciente. Método: estudio cualitativo, descriptivo y exploratorio, realizado en un hospital público de Pernambuco, Brasil. Participaron seis enfermeras que trabajaban en la unidad pediátrica. La recogida de datos se llevó a cabo entre noviembre y febrero de 2021 mediante entrevistas semiestructuradas, el análisis de datos se realizó mediante investigación de contenido. Resultados: se identificaron tres categorías a partir del análisis de los resultados, siendo éstas la percepción de las enfermeras sobre la seguridad del paciente, las barreras de identificación del paciente en la unidad pediátrica y las barreras de identificación: estrategia para mitigar los errores en la unidad pediátrica. Consideraciones finales: Fue posible notar que las enfermeras creen en la importancia de la identificación del paciente como estrategia para minimizar la ocurrencia de errores relacionados a la medicación y destacan que este acto proporciona mayor seguridad a los profesionales durante la ejecución de los procedimientos.

Objective to identify the perception of nurses who work in a pediatric unit about patient safety measures. Method: qualitative, descriptive and exploratory study, conducted in a public hospital in Pernambuco, Brazil. Six pediatric nurses participated. Data collection was conducted between November and February 2021 through semi-structured interviews; data analysis was conducted through content investigation. Results: three categories were identified from the analysis of the Results: nurses' perception of patient safety, patient identification barriers in the pediatric unit, and identification wristbands: a strategy to mitigate errors in the pediatric unit. Final considerations: it was possible to realize that nurses believe in the importance of patient identification as a strategy to minimize the occurrence of medication-related errors and emphasize that this act provides greater safety to professionals during the execution of procedures.

Acute kidney injury among hospitalised patients who died due to COVID-19 in the Eastern Cape, South Africa

Background: Acute kidney injury (AKI) commonly occurs in coronavirus disease 2019 (COVID-19) patients who have been hospitalised and is associated with a poor prognosis. This study aimed to determine the incidence of AKI among COVID-19 patients who died in a regional hospital in South Africa. Methods: This retrospective record review was conducted at the Mthatha Regional Hospital in South Africa's Eastern Cape province. Data were collected between 10 July 2020 and 31 January 2021. Results: The incidence of AKI was 38% among the hospitalised patients who died due to COVID-19. Most study participants were female, with a mean age of 63.3 ± 16 years. The most common symptom of COVID-19 at the time of hospitalisation was shortness of breath, followed by fever and cough. Half of the patients had hypertension, while diabetes, human immunodeficiency viruses (HIV) and tuberculosis (TB) were other comorbidities. At admission, the average oxygen saturation was 75.5% ± 17. Conclusion: The study revealed a high incidence of AKI among hospitalised patients who died due to COVID-19. It also found that those received adequate crystalloid fluids at the time of admission had a lower incidence of AKI. Contribution: Acute kidney injury can be prevented by adequate fluid management during early stage of COVID-19. Majority of COVID-19 patients were referred from lower level of care and primary care providers have their first encounter with these patients. Adequate fluid resuscitation in primary care settings can improve the outcome of hospitalised COVID-19 patients.

Aspects cliniques et pronostiques des accidents vasculaires cérébraux en réanimation au Cameroun / Clinical and prognostic aspects of stroke in a Cameroonian intensive care unit

Introduction. L'accident vasculaire cérébral (AVC) est une pathologie fréquente. Le but de l'étude était de décrire les aspects pronostiques des AVC en réanimation. Patients et Méthodes. Il s'agissait d'une étude longitudinale descriptive et analytique, qui s'est déroulée de janvier à avril 2019. Nous avons recruté dans les services de réanimation de trois hôpitaux universitaires de Yaoundé. Etait inclus, tout patient hospitalisé en réanimation pour prise en charge d'un AVC, ayant réalisé un scanner cérébral. Le consentement était obtenu auprès du patient ou d'un parent. Les variables étaient les données sociodémographiques, les données cliniques et pronostiques.Les données étaient analysées à partir du logiciel Epi info 3.5.4 et Microsoft Office Excel 2013. Les proportions étaient comparées par le test de Chi carré ou le test exact de Fisher. Les médianes étaient comparées par le test de MannWhitney. La survie était représentée par une courbe de Kaplan Meier. Résultats. Au total, 34 patients étaient inclus. L'âge moyen était de 59,9±9,7 ans. Le sex-ratio était de 0,7. Le délai moyen d'admission était de 4,5±4,84 jours. L'hypertension artérielle était le facteur de risque dominant (42,5%). Une altération de la conscience était fréquente (73,5%). L'hémiplégie constituait le principal signe neurologique focal. L'AVC hémorragique était retrouvé chez 58,8% des patients. Deux patients étaient intubés (5,88%). Dix-huit décès étaient enregistrés (52,9%). La durée moyenne du séjour était de 21,8±19,4 jours. Les facteurs pronostiques étaient le score de Glasgow <8 (P=0,01), le score de NIHSS≥15 (P=0,001), l'hyperthermie (P=0,04), la présence de trouble de la déglutition à l'entrée (P=0,01) et l'effet de masse au scanner cérébral (P=0,01). Conclusion. Les AVC restent une affection fréquente dans notre pays. La mortalité est élevée.Elle est liée à la gravité clinique et la survenue des complications

Background. Stroke is a frequent pathology. The aim of the study was to describe the clinical, and prognostic aspects of stroke in the intensive care unit (ICU). Patients and Methods. This was a longitudinal descriptive and analytical study, which took place from January to April 2019. We recruited from the intensive care units of three university hospitals in Yaoundé. Any patient hospitalised in the ICU for stroke management who had undergone a brain scan was included. Consent was obtained from the patient or a relative. The variables were socio-demographic data, clinical data, therapeutic data and outcome. Data were analysed using Epi info 3.5.4 and Microsoft Office Excel 2013. Proportions were compared using the Chi-square test or Fisher's exact test. Medians were compared by the Mann-Whitney test. Survival was represented by a Kaplan Meier curve. Results. A total of 34 patients were included. The mean age was 59.9±9.7 years. The sex ratio was 0.7. The mean time to admission was 4.5 days ±4.84. Hypertension was the dominant risk factor (42.5%). Altered consciousness was common (73.5%). Hemiplegia was the main focal neurological sign. Hemorrhagic stroke was found in 58.8% of the patients. All patients received general measures. Two patients were intubated (5.88%). Eighteen deaths were recorded (52.9%). The average length of stay was 21.8±19.4 days. Prognostic factors were Glasgow score <8 (P=0.01), NIHSS score≥15 (P=0.001), hyperthermia (P=0.04), presence of swallowing disorder at admission (P=0.01) and mass effect on brain scan (P=0.01). Conclusion. Stroke remains a frequent condition in our country. Mortality is high. It is related to the clinical severity and the occurrence of complications.

Prise en charge médicale du premier épisode de bronchiolite aiguë des nourrissons de moins de 12 mois hospitalisés au CHU de Cocody de 2020 à 2022 / Medical management of first episode of acute bronchiolitis in children less than 12 months old hospitalized at Cocody University Hospital from 2020 to 2022

Introduction. La bronchiolite aiguë du nourrisson est une infection virale des voies aériennes inférieures qui représente un problème majeur de santé publique. L'objectif de cette étude était de décrire la prise en charge médicale du premier épisode de bronchiolite aiguë au CHU de Cocody. Méthodes. Il s'agissait d'une étude rétrospective à visée descriptive qui a consisté à décrire la prise en charge médicale des nourrissons hospitalisés dans le CHU de Cocody du 1er Janvier 2020 au 31 Décembre 2022. Résultats : Sur la période d'étude, 125 nourrissons sont hospitalisés pour bronchiolite aiguë. La tranche d'âge de 4 à 6 mois était majoritaire (49,6%). L'âge moyen des patients est de 4,7 mois avec des extrêmes de 1 à 12 mois (écart-type=1,277 mois). Le sex-ratio était de 1,27. La numération formule anguine (NFS), la C Reactive Protein (CRP) et la radiographie thoracique standard ont été réalisées chez tous les patients. La désobstruction rhino-pharyngée (DRP) a été pratiquée dans 96,0% des cas. Une nébulisation avec du salbutamol a été appliquée à tous les patients. Cette nébulisation a été associée à une antibiothérapie (71,2 %), une corticothérapie (52 %) et à une kinésithérapie respiratoire (48 %). L'évolution a été favorable dans 96 % des cas, malgré une sous-utilisation de la ventilation non-invasive dans notre dans notre contexte. Conclusion : L'analyse de la prise en charge de la bronchiolite aiguë du nourrisson au CHU de Cocody, a revélé des écarts par rapport aux recommandations de la HAS française. Il serait judicieux d'établir un consensus national adapté à notre contexte de travail.

Acute bronchiolitis in infants is a viral infection of the lower airways that represents a major public health problem. The main objective was to describe the management of this condition in the Ivorian pediatric hospital context. Methods. This was a descriptive cross-sectional study, with retrospective data collection. We have described the care of infants aged 1 month to 12 months, hospitalized for bronchiolitis in the Pediatrics department of the CHU of Cocody from January 01, 2020 to December 31, 2022. Results. We collected 125 files. The age group of 4 to 6 months was the majority (49.6%). The average age of the patients was 4.7 months (ecart-type=1,277 months) with extremes of 1 to 12 months. The sex ratio was 1.27. NFS, CRP and AP chest X-ray were performed in all patients. Nasopharyngeal clearance was performed in 96.0% of cases. The infants were all nebulized with salbutamol. Among them, 52% received a corticosteroid, 71.2% antibiotic therapy and in 48% of cases respiratory physiotherapy was performed. The evolution was favorable in 96% of cases. Conclusion : The analysis of the management of acute bronchiolitis in infants at the Cocody University Hospital reveals deviations from the recommendations of the French HAS. It would be wise to establish a national consensus adapted to our work context.

Motivos de interrupção da nutrição enteral em unidades de terapia intensiva / Reasons of interruption in enteral nutrition in intensive care units

Esta pesquisa busca identificar as causas de interrupção da administração da nutrição enteral em pacientes internados em unidades de terapia intensiva do Hospital de Urgências da cidade de Goiânia. Objetivo: Chegar às causas de interrupção da administração da nutrição enteral em pacientes internados em Unidades de Terapia Intensiva (UTIs). Método: Estudo transversal, prospectivo, realizado com pacientes internados nas UTIs do Hospital de Urgências de Goiás, no período de maio e junho de 2022. Foram coletadas as seguintes variáveis: sexo, idade, peso, altura, IMC, diagnóstico de internação, data de internação, desfecho clínico do paciente, causas de interrupção da dieta enteral, volume prescrito e volume infundido no prontuário. Os dados foram coletados até o sétimo dia de internação e acompanhados até o desfecho clínico (alta, óbito ou transferência). Resultados: Foram obtidos dados de 45 pacientes. As principais causas de interrupção da NE foram instabilidade hemodinâmica (28,2%), jejum para exames (19%) e intolerância gastrointestinal (19%). A adequação de volume prescrito comparado com o infundido foi de 86,4%. Conclusão: Quando agrupadas as causas evitáveis representam 71,4%, enquanto a causa não evitável representa 28,6%. O tempo de retenção é controlável e, portanto, os esforços devem ser direcionados a estratégias eficientes com a equipe multiprofissional, como capacitações quanto às causas das interrupções e soluções para minimizar o tempo da retenção da dieta

This research seeks to identify the causes of interruption in the administration of enteral nutrition in patients hospitalized in intensive care units at Hospital de Urgências in the city of Goiânia. Objective: Get to the causes of interruption of the administration of enteral nutrition in patients hospitalized in Intensive Care Units (ICUs). Method: A cross-sectional, prospective study carried out with patients admitted to the ICUs of the Hospital de Urgências de Goiás, between May and June 2022. The following variables were collected: sex, age, weight, height, BMI, hospitalization diagnosis, date length of stay, clinical outcome of the patient, causes of enteral diet interruption, volume prescribed and volume infused in the medical record. Data were collected up to the seventh day of hospitalization and followed up until the clinical outcome (discharge, death or transfer). Results: Data from 45 patients were obtained. The main causes of EN interruption were hemodynamic instability (28.2%), fasting for exams (19%) and gastrointestinal intolerance (19%). The adequacy of prescribed volume compared to infused volume was 86.4%. Conclusion: The three main causes of diet interruption were hemodynamic instability, gastrointestinal intolerance due to emesis and fasting for exams. The retention time is controllable and, therefore, efforts should be directed towards efficient strategies with the multidisciplinary team, such as training on the causes of interruptions and solutions to minimize the time of diet retention

Perfil epidemiológico de pacientes vítimas de trauma torácico em um hospital de urgência e trauma / Epidemiological profile of patients victims of thoracic trauma in an emergency and trauma hospital

O trauma é responsável por significativos impactos na sociedade. De acordo com dados da Organização Mundial de Saúde (OMS), mais de nove pessoas morrem por minuto, vítimas de trauma. Entre os principais tipos de trauma, o torácico representa na atualidade cerca de 25% dos mortos em politraumatizados, constituindo um problema complexo, tendo em vista os elevados índices de mortalidade e sequelas incapacitantes permanentes. Objetivo: Descrever o perfil epidemiológico dos pacientes atendidos em um hospital de urgências da região centro-oeste, vítimas de trauma torácico. Método: Estudo quantitativo, de caráter transversal e retrospectivo, realizado a partir de coleta de dados efetuada em prontuário eletrônico no período de março a maio de 2022. Resultados: Identificou-se 73 pacientes vítimas de trauma torácico, com maior acometimento de pessoas do sexo masculino, com idade entre 26 e 35 anos. Como causa mais frequente, se destacaram os acidentes motociclísticos, resultando principalmente em lesões do tipo hemopneumotórax. Conclusão: o perfil epidemiológico dos pacientes vítimas de trauma torácico foi representado com maior frequência pelo sexo masculino, com idade entre 26 a 35 anos, causados predominantemente por acidentes motociclísticos, resultando na maioria das vezes em lesões do tipo hemopneumotórax

Trauma is responsible for significant impacts on society. According to data from the World Health Organization (WHO), more than nine people die per minute victims of trauma. Among the main types of trauma, thoracic trauma currently represents about 25% of polytrauma deaths, constituting a complex problem, in view of the high rates of mortality and sequelae permanent disabling. Objective: To describe the epidemiological profile of patients treated at an emergency hospital in the Midwest region, victims of thoracic trauma. Method: Quantitative, cross-sectional and retrospective study carried out from data collection of electronic medical records in the period from March to May of 2022. Results: We identified 73 patients who were victims of chest trauma with higher affecting males aged between 26 and 35 years. As the most frequent cause motorcycle accidents stood out, resulting mainly in lesions of the hemopneumothorax type. Conclusion: the profile epidemiology of patients victims of thoracic trauma was represented with greater frequency by males, aged between 26 and 35 years, caused predominantly by motorcycle accidents, often resulting in hemopneumothorax lesions

Effect of diurnal temperature range on the number of elderly inpatients with ischemic stroke in Hunan Province / 中华预防医学杂志

Objective: To study the effect of diurnal temperature range on the number of elderly inpatients with ischemic stroke in Hunan Province. Method: Demographic and disease data, meteorological data, air quality data, population, economic and health resource data of elderly inpatients with ischemic stroke were collected in 122 districts/counties of Hunan Province from January to December 2019. The relationships between the diurnal temperature range and the number of elderly inpatients with ischemic stroke were analyzed by using the distributed lag non-linear model, including the cumulative lag effect of the diurnal temperature range in different seasons, extremely high diurnal temperature range and extremely low diurnal temperature range. Results: In 2019, 152 875 person-times were admitted to the hospital for ischemic stroke in the elderly in Hunan Province. There was a non-linear relationship between the diurnal temperature range and the number of elderly patients with ischemic stroke, with different lag periods. In spring and winter, with the decrease in diurnal temperature range, the risk of admission of elderly patients with ischemic stroke increased (Ptrend<0.001, Ptrend=0.002);in summer, with the increase in diurnal temperature range, the risk of admission of elderly patients with ischemic stroke increased (Ptrend=0.024);in autumn, the change in the diurnal temperature range would not cause a change in admission risk (Ptrend=0.089). Except that the lag effect of the extremely low diurnal temperature range in autumn was not obvious, the lag effect occurred in other seasons under extremely low and extremely high diurnal temperature ranges. Conclusion: The high diurnal temperature range in summer and the low diurnal temperature range in spring and winter will increase the risk of admission of elderly patients with ischemic stroke, and the risk of admission of elderly patients with ischemic stroke will lag under the extremely low and extremely high diurnal temperature ranges in the above three seasons.

Low diastolic blood pressure and adverse outcomes in inpatients with acute exacerbation of chronic obstructive pulmonary disease: A multicenter cohort study / 中华医学杂志(英文版)

BACKGROUND@#Although intensively studied in patients with cardiovascular diseases (CVDs), the prognostic value of diastolic blood pressure (DBP) has little been elucidated in patients with acute exacerbation of chronic obstructive pulmonary disease (AECOPD). This study aimed to reveal the prognostic value of DBP in AECOPD patients.@*METHODS@#Inpatients with AECOPD were prospectively enrolled from 10 medical centers in China between September 2017 and July 2021. DBP was measured on admission. The primary outcome was all-cause in-hospital mortality; invasive mechanical ventilation and intensive care unit (ICU) admission were secondary outcomes. Least absolute shrinkage and selection operator (LASSO) and multivariable Cox regressions were used to identify independent prognostic factors and calculate the hazard ratio (HR) and 95% confidence interval (CI) for adverse outcomes.@*RESULTS@#Among 13,633 included patients with AECOPD, 197 (1.45%) died during their hospital stay. Multivariable Cox regression analysis showed that low DBP on admission (<70 mmHg) was associated with increased risk of in-hospital mortality (HR = 2.16, 95% CI: 1.53-3.05, Z = 4.37, P <0.01), invasive mechanical ventilation (HR = 1.65, 95% CI: 1.32-2.05, Z = 19.67, P <0.01), and ICU admission (HR = 1.45, 95% CI: 1.24-1.69, Z = 22.08, P <0.01) in the overall cohort. Similar findings were observed in subgroups with or without CVDs, except for invasive mechanical ventilation in the subgroup with CVDs. When DBP was further categorized in 5-mmHg increments from <50 mmHg to ≥100 mmHg, and 75 to <80 mmHg was taken as reference, HRs for in-hospital mortality increased almost linearly with decreased DBP in the overall cohort and subgroups of patients with CVDs; higher DBP was not associated with the risk of in-hospital mortality.@*CONCLUSION@#Low on-admission DBP, particularly <70 mmHg, was associated with an increased risk of adverse outcomes among inpatients with AECOPD, with or without CVDs, which may serve as a convenient predictor of poor prognosis in these patients.@*CLINICAL TRIAL REGISTRATION@#Chinese Clinical Trail Registry, No. ChiCTR2100044625.

Inpatient Parkinson’s care: Challenges and special considerations

@#The hospital is often a haven for people in need of care. However, for people with Parkinson’s disease (PD), hospitalizations can turn into a nightmare. People with PD are admitted to the hospital more frequently than those without PD. Infections, metabolic changes, exposure to anesthesia, changes in medication regimen or new medication changes are some common factors that may worsen PD symptoms during hospitalization. More importantly, the inherent complexity of PD pathophysiology creates challenges in management. Therefore, understanding PD pathophysiology and recognizing care gaps enable optimization of inpatient care among this vulnerable population.

Prevalence, patterns and prognosis of multimorbidity among middle-aged and elderly inpatients with chronic obstructive pulmonary disease / 中华预防医学杂志

Objective: To explore the characteristics, patterns of multimorbidity and the impact on quality of life and the prognosis of middle-aged and elderly patients with chronic obstructive pulmonary disease (COPD). Methods: This is a cross-sectional study. From January 2012 to December 2021, 939 middle-aged and elderly COPD patients hospitalized in Beijing Hospital were selected by the convenient sampling method. The basic data of patients and the date of 16 common chronic diseases were collected. Patterns of multimorbidity were depicted by cluster analysis. Generalized linear regression model and logistic regression were used to evaluate the multimorbidity patterns and their prognosis. Results: At least one multimorbidity existed among 93.40% of COPD patients, and the median number of multimorbidity was 3. The top five multimorbidity among the patients were hypertension (57.93%, 544/939), coronary heart disease (33.76%,317/939), heart failure (31.95%,300/939), hyperlipidemia (31.63%,297/939) and arrhythmia (27.37%,257/939). Four multimorbidity patterns were identified, cardiometabolic and metabolic multimorbidity, kidney disease multimorbidity, respiratory-digestive-tumor multimorbidity and other multimorbidity. Cardiometabolic and metabolic multimorbidity was most common (590/939, 62.83%). Compared with non-cardiometabolic and metabolic multimorbidity, the incharge ADL score of patients with this multimorbidity decreased by 7 points (95%CI:-11.22- -3.34), Correspondingly, patients with kidney disease multimorbidity decreased by 14 points (95%CI:-24.12- -3.30) on the incharge score. The presence or absence of kidney disease multimorbidity had the greatest impact on discharge score, which was reduced by 12 points in comparison with patients without this multimorbidity (95%CI:-22.43- -2.40). ICU admission is mostly affected by the presence of cardiometabolic and metabolic multimorbidity (OR=2.44, 95%CI: 1.51-3.92) and kidney disease multimorbidity (OR=2.58, 95%CI: 1.01-6.60). The risk of death is the highest for cardiometabolic and metabolic multimorbidity (OR=2.24, 95%CI: 1.19-4.21). Conclusion: Multimorbidity is common in COPD patients. The most common pattern is cardiometabolic and metabolic multimorbidity. Cardiometabolic and metabolic multimorbidity and kidney disease multimorbidity significantly affect the quality of life and often associate with a poor prognosis.

Comparison of hospital delivery costs between cesarean section and natural delivery and analysis of influencing factors / 中南大学学报(医学版)

OBJECTIVES@#The increasing costs of hospital delivery have increased the economic burden of pregnant women, and the mode of delivery is the main factor affecting the costs of hospital delivery. This study aims to explore the difference in costs between cesarean section and natural delivery, and to provide reference for controlling the increase of hospital delivery costs.@*METHODS@#The data of inpatient delivery in the Hunan Maternal and Child Health Care Hospital from January 2016 to December 2020 were selected to compare the total inpatient costs and average daily costs of cesarean section and natural delivery. The linear trend model was used to analyze the trend change of inpatient delivery costs and the generalized linear model was used to analyze the influential factors for inpatient delivery costs.@*RESULTS@#The average hospitalization costs of cesarean section (10 447.25 yuan) were higher than that of natural delivery (5 567.95 yuan), and the average daily costs of cesarean section (1 902.57 yuan) were higher than those of natural delivery (1 666.40 yuan). There was no significant increase or decrease in trend for cesarean section, while the average annual growth rate of the costs of natural delivery was 11.79%. The main factors affecting the hospitalization costs of cesarean section and natural delivery included age, occupation, medical insurance, route of admission, length of stay, premature delivery and complications (all P<0.05).@*CONCLUSIONS@#The total hospitalization costs and average daily costs of cesarean section are higher than those of natural delivery, but the costs of natural delivery show a faster growth trend, and the hospitalization costs of cesarean section and natural delivery should be controlled by targeted measures.

Experiências de puérperas no contato pele a pele com recém-nascido na primeira hora pós-parto / Experiencias de puérperas en contacto piel con recién nacido en la primera hora postparto / Experiences of puerperal women in skin-to-skin contact with newborns in the first postpartum hour

Objetivo: descrever experiência de puérperas sobre o contato pele a pele com o recém-nascido na primeira hora após o parto. Método: pesquisa qualitativa, realizada no Alojamento Conjunto do Hospital Universitário da Universidade de São Paulo, Brasil. Foram entrevistadas 20 puérperas entre julho e dezembro de 2019. Utilizou-se a análise de conteúdo, com auxílio do software Atlas.ti 9. Resultados: foram desveladas três categorias: Surpreendendo-se com a experiência do contato pele a pele; Sentimentos ambivalentes em relação ao contato pele a pele; e Refletindo sobre ações dos profissionais quanto ao contato pele a pele. Considerações finais: a experiência foi considerada positiva e diferente de experiências anteriores, apesar da insegurança e do acesso limitado a informações desde o pré-natal. O contato pele a pele não implica em gastos adicionais, não oferece riscos para o binômio, proporciona alta qualidade no atendimento, contribuindo para a satisfação da mulher e benefícios à saúde do recém-nascido.

Objetivo: describir la experiencia de las puérperas sobre el contacto piel con piel con el recién nacido en la primera hora después del parto. Método: investigación cualitativa, realizada en el Alojamiento Conjunto del Hospital Universitário da Universidade de São Paulo, Brasil. Fueron entrevistadas 20 puérperas entre julio y diciembre de 2019. Se utilizó el análisis de contenido, con ayuda del software Atlas.ti 9. Resultados: fueron desveladas tres categorías: Sorprendiéndose con la experiencia del contacto piel a piel; Sentimientos ambivalentes en relación al contacto piel a piel; y reflexionando sobre las acciones de los profesionales en cuanto al contacto piel con piel. Consideraciones finales: la experiencia se consideró positiva y diferente de experiencias anteriores, a pesar de la inseguridad y el acceso limitado a la información desde el prenatal. El contacto piel a piel no implica gastos adicionales, no ofrece riesgos para el binomio, proporciona alta calidad en la atención, contribuyendo para la satisfacción de la mujer y beneficios para la salud del recién nacido.

Objective: to describe experience of puerperal women on skin-to-skin contact with the newborn in the first hour after delivery. Method: qualitative research, carried out in the Joint Accommodation of the Hospital Universitário da Universidade de São Paulo, Brazil. 20 puerperal women were interviewed between July and December 2019. Content analysis was used, using the Atlas.ti 9 software. Results: three categories were unveiled: Surprising with the experience of skin-to-skin contact; Ambivalent feelings regarding skin-to-skin contact; and Reflecting on the actions of professionals regarding skin-to-skin contact. Final considerations: the experience was considered positive and different from previous experiences, despite insecurity and limited access to information since prenatal care. Skin-to-skin contact does not imply additional expenses, does not pose risks to the binomial, provides high quality care, contributing to the satisfaction of the woman and health benefits of the newborn.

Complications of herpes zoster hospitalizations in a reference hospital in Fortaleza-Ceará, 2009-2018 / Complicações de internações por herpes zoster em um hospital de referência em Fortaleza-Ceará, 2009-2018

Objective: the aim of this study was to relate sociodemographic, epidemiological and clinical conditions to the occurrence of severe cases of HZ in reference hospital of Fortaleza. Methods: this is a cross-sectional analytical study, based on medical records of patients admitted from 2009 to 2018. Pearson's x2 test or Fisher's exact test were used when appropriate. Results: we analyzed 196 medical records. The presence of complications occurred in 69.9%, the most affected region was the cranial (68.9%), and 1.5% died. The presence of vesicles (PR=1.37; 95%CI: 1.03-1.82; p=0.01) and the choice of antibiotic associated antiviral therapy (PR=0.58; 95%CI: 0.46-0.73; p=0.00) were significantly associated with the severity. Conclusions: the disease may be more severe at ages over 50. The presence of lesions in vesicles was associated with a higher prevalence of complications and the use of antibiotics and antivirals as a protective factor.

Objetivo: relacionar condições sociodemográficas, epidemiológicas e clínicas à ocorrência de casos graves de HZ em hospital de referência de Fortaleza. Métodos: trata-se de um estudo analítico transversal, baseado em prontuários de pacientes internados de 2009 a 2018. Foram utilizados o teste x2 de Pearson ou o teste exato de Fisher, quando apropriado. Resultados: foram analisados 196 prontuários. A presença de complicações ocorreu em 69,9%, a região mais acometida foi a craniana (68,9%), e 1,5% foi a óbito. A presença de vesículas (RP=1,37; IC95%: 1,03-1,82; p=0,01) e a escolha da terapia antiviral associada a antibióticos (RP=0,58; IC95%: 0,46-0,73; p=0,00) foram significativamente associadas com a gravidade. Conclusões: a doença pode ser mais grave a partir dos 50 anos. A presença de lesões em vesículas foi associada à maior prevalência de complicações e o uso de antibióticos e antivirais como fator de proteção.

Trauma em ambientes rurais: avaliação de pacientes internados em unidade de terapia intensiva / Trauma in rural environments: evaluation of patients interned in intensive care unit / Traumatismos en entornos rurales: evaluación de los pacientes ingresados en una unidad de cuidados intensivos

O acesso limitado do atendimento ao trauma aumenta proporcionalmente à ruralidade, refletindo em uma maior mortalidade e invalidez a longo prazo. A pesquisa objetivou identificar os desfechos de pacientes internados por trauma em Unidades de Terapia Intensiva, acometidos em ambientes rurais. Trata-se de um estudo transversal observacional realizado em uma UTI geral de um hospital da região central do Estado do Paraná entre 2013 a 2019, através da análise de prontuários de 230 pacientes traumatizados em ambiente rural. Os dados foram analisados por meio de testes de Qui-quadrado de Pearson, exato de Fisher ou t de Student. Dentre os desfechos identificados, observou-se associação do sexo feminino com as comorbidades (p=0,024), das regiões mais afetadas de cabeça, pescoço e tórax com a gravidade do trauma (p=0,001), além de variáveis do primeiro atendimento, como suporte respiratório básico, PAS <90mmHg e Glasgow associados à pacientes cirúgicos e pupilas alteradas em pacientes clínicos. Para o desfecho, observou-se que as médias do tempo de permanência hospitalar foi significativamente menor para aqueles que foram a óbito. As características apresentadas assemelham-se às informações mencionadas na literatura, em que as lesões graves com a necessidade de intervenção cirúrgica e maior tempo de permanência hospitalar estão associados ao óbito em traumas rurais. Contudo, o trauma no ambiente rural, apesar de não refletir nem sempre em maior gravidade, apresenta desfechos impactantes para o paciente.

Limited access to trauma care increases proportionally to rurality, reflecting higher mortality and long-term disability. The research aimed to identify the outcomes of patients hospitalized for trauma in Intensive Care Units, affected in rural environments. This is an observational cross-sectional study carried out in a general ICU of a hospital in the central region of the State of Paraná between 2013 and 2019, through the analysis of medical records of 230 trauma patients in a rural environment. Data were analyzed using Pearson's chi-square, Fisher's exact or Student's t tests. Among the outcomes identified, there was an association between female sex and comorbidities (p=0.024), the most affected regions of the head, neck and chest with the severity of the trauma (p=0.001), in addition to variables of the first care, such as basic respiratory support, SBP <90mmHg and Glasgow associated with surgical patients and altered pupils in medical patients. For the outcome, it was observed that the average length of hospital stay was significantly lower for those who died. The characteristics presented are similar to the information mentioned in the literature, in which serious injuries requiring surgical intervention and longer hospital stays are associated with death in rural traumas. However, trauma in the rural environment, although not always reflecting greater severity, has impacting outcomes for the patient.

El acceso limitado a la atención traumatológica aumenta proporcionalmente a la ruralidad, lo que se refleja en una mayor mortalidad y discapacidad a largo plazo. La investigación tenía como objetivo identificar los resultados de los pacientes ingresados por traumatismos en las Unidades de Cuidados Intensivos, afectados en entornos rurales. Se trata de un estudio observacional transversal realizado en una UCI general de un hospital de la región central del Estado de Paraná entre 2013 y 2019, a través del análisis de las historias clínicas de 230 pacientes lesionados en el medio rural. Los datos se analizaron mediante las pruebas de chi-cuadrado de Pearson, exacta de Fisher o t de Student. Entre los resultados identificados, el sexo femenino se asoció con las comorbilidades (p=0,024), las regiones más afectadas de la cabeza, el cuello y el tórax con la gravedad del traumatismo (p=0,001), además de las variables de los primeros cuidados, como la asistencia respiratoria básica, la PAS <90mmHg y el Glasgow asociado a los pacientes quirúrgicos y las pupilas alteradas en los pacientes clínicos. En cuanto al resultado, se observó que la duración media de la estancia hospitalaria fue significativamente menor para los que murieron. Las características presentadas son similares a la información mencionada en la literatura, en la que las lesiones graves con necesidad de intervención quirúrgica y mayor estancia hospitalaria se asocian a la muerte en el trauma rural. Sin embargo, el traumatismo en el medio rural, a pesar de no reflejar siempre una mayor gravedad, presenta resultados impactantes para el paciente.

El trastorno del lenguaje de las personas con esquizofrenia y su relación con la gravedad y la funcionalidad / The language disorder of people with schizophrenia and its relationship with severity and functionality

RESUMEN: Objetivo: estudiar las características del lenguaje en pacientes que padecen esquizofrenia u otros trastornos psicóticos. Método: 55 pacientes diagnosticados de esquizofrenia (50) y trastorno esquizoafectivo (5). Se aplica la escala TLC de Andreasen, la escala EEAG para la funcionalidad, la CGI para la gravedad. Se recogen datos sociodemográficos. Resultados: Las medias son: edad: 61,47 años, internamiento: 19,47 años, CGI: 5,8, EEAG: 32,5. La subescala de desconexión de la TLC puntúa de media: 8,43, y la de Subproducción verbal: 1,2. La desconexión correlaciona negativamente con EEAG, y positivamente con CGI. La Subproducción verbal correlaciona con CGI. Conclusiones: Los participantes presentan un grado de gravedad elevado y de funcionalidad bajo. Presentan alteraciones importantes del lenguaje, particularmente de pobreza del habla, pero también de desconexión verbal. Con puntuaciones que varían de leve a moderado. Ambas subescalas correlacionan con gravedad. Además, la desconexión es mayor en los pacientes con peor funcionalidad. La alteración del lenguaje en esquizofrenia está relacionada con la gravedad y la funcionalidad, lo cual tiene importantes consecuencias en la vida de las personas que padecen esta enfermedad.

ABSTRACT Objective: to study the characteristics of language in patients suffering from schizophrenia or other psychotic disorders. Method: 55 patients diagnosed with schizophrenia (50) and schizoaffective disorder (5). The Andreasen TLC scale, the EEAG scale for functionality and the CGI for gravity are applied. Sociodemographic data are collected. Results: Mean age: 61.47 years, mean years hospitalized: 19.47 years, CGI: 5.8, EEAG: 32.5. The TLC disconnection subscale scores on average: 8.43, and the Verbal Underproduction: 1.2. Disconnection correlates negatively with EEAG, and positively with CGI. Verbal underproduction correlates with CGI. Conclusions: The participants present a high degree of severity and low functionality. They present significant language alterations, poor speech, and verbal disconnection. With scores ranging from mild to moderate. Both subscales correlate with severity. In addition, the Disconnection is greater in patients with worse functionality. Language impairment in schizophrenia is related to severity and functionality, which has important consequences in the lives of people with this disease.